SpoIIP

• Description: cell wall hydrolase with both amidase and endopeptidase activities, required for dissolution of the septal cell wall
  
  

Gene name	spoIIP
Synonyms
Essential	no
Product	cell wall hydrolase
Function	dissolution of the septal cell wall
MW, pI	44 kDa, 6.852
Gene length, protein length	1203 bp, 401 aa
Immediate neighbours	yqxA, gpr
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU25530

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: removes the stem peptides from the cell wall and cleaves the cross-links between them PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: activity is stimulated by interaction with SpoIID PubMed

• Interactions: SpoIID-SpoIIP PubMed

• Localization: cell membrane PubMed

Database entries

• Structure:

• UniProt: P37968

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIP-yqxA PubMed, gpr-spoIIP PubMed

• Sigma factor:
  • spoIIP: SigE PubMed
  • gpr:SigF PubMed

• Regulation: expressed early during sporulation (SigE,SigF) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: