WalK

• Description: two-component sensor kinase, controls cell wall metabolism
  
  

Gene name	walK
Synonyms	yycG
Essential	yes PubMed
Product	two-component sensor kinase (OmpR family)
Function	control of cell wall metabolism
MW, pI	69 kDa, 4.775
Gene length, protein length	1833 bp, 611 aa
Immediate neighbours	yycH, walR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU40400

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of WalR

• Protein family: two-component sensor kinase of the OmpR family

• Paralogous protein(s):

Genes controlled by WalR PubMed

• activated by WalR-P: cwlO, lytE, ydjM, yocH
• repressed by WalR-P: iseA

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:

• Interactions: WalK-WalR

• Localization: cell membrane (according to Swiss-Prot), part of the division septum in growing cells PubMed

Database entries

• Structure:

• UniProt: Q45614

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: walR-walK-yycH-yycI-yycJ-yyxA PubMed

• Sigma factor:

• Regulation: expressed during vegetative growth, repressed during stationary phase PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: