NsrR

• Description: nitric oxide-responsive regulator
  
  

Gene name	nsrR
Synonyms	yhdE
Essential	no
Product	transcriptional repressor
Function	upregulation of ResD-ResE-dependent genes in the presence of nitric oxide (NO)
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	16 kDa, 7.75
Gene length, protein length	438 bp, 146 aa
Immediate neighbours	lytF, ygxB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU09380

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: nitric oxide (NO) acts as molecular inducer and results in NsrR release from its DNA targets

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O07573

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: nsrR PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Erik T Yukl, Mohamed A Elbaz, Michiko M Nakano, Pierre Moënne-Loccoz
Transcription Factor NsrR from Bacillus subtilis Senses Nitric Oxide with a 4Fe-4S Cluster (†).
Biochemistry: 2008, 47(49);13084-92
[PubMed:19006327] [WorldCat.org] [DOI] (I p)

Annika Rogstam, Jonas T Larsson, Peter Kjelgaard, Claes von Wachenfeldt
Mechanisms of adaptation to nitrosative stress in Bacillus subtilis.
J Bacteriol: 2007, 189(8);3063-71
[PubMed:17293416] [WorldCat.org] [DOI] (P p)

Michiko M Nakano, Hao Geng, Shunji Nakano, Kazuo Kobayashi
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
J Bacteriol: 2006, 188(16);5878-87
[PubMed:16885456] [WorldCat.org] [DOI] (P p)