FatR

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  • Description: transcriptional repressor of the fatR-yrhJ operon

Gene name fatR
Synonyms yrhI, bscR
Essential no
Product transcriptional repressor
of the fatR yrhJ operon (TetR family)
Function unknown
MW, pI 22 kDa, 5.621
Gene length, protein length 582 bp, 194 aa
Immediate neighbours yrhJ, yrhH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YrhI context.gif
This image was kindly provided by SubtiList




The gene

Basic information

  • Locus tag: BSU27170

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by unsaturated fatty acids (FatR)
  • Regulatory mechanism: FatR: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

M C Gustafsson, C N Palmer, C R Wolf, C von Wachenfeldt
Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species.
Arch Microbiol: 2001, 176(6);459-64
[PubMed:11734890] [WorldCat.org] [DOI] (P p)

T R Lee, H P Hsu, G C Shaw
Transcriptional regulation of the Bacillus subtilis bscR-CYP102A3 operon by the BscR repressor and differential induction of cytochrome CYP102A3 expression by oleic acid and palmitate.
J Biochem: 2001, 130(4);569-74
[PubMed:11574077] [WorldCat.org] [DOI] (P p)

M C Gustafsson, C von Wachenfeldt
A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter.
FEMS Microbiol Lett: 2001, 199(2);197-202
[PubMed:11377867] [WorldCat.org] [DOI] (P p)