PheS

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  • Description: phenylalanyl-tRNA synthetase (alpha subunit)

Gene name pheS
Synonyms
Essential yes PubMed
Product phenylalanyl-tRNA synthetase (alpha subunit)
Function translation
Metabolic function and regulation of this protein in SubtiPathways:
tRNA charging
MW, pI 38 kDa, 5.083
Gene length, protein length 1032 bp, 344 aa
Immediate neighbours pheT, ysgA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PheS context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU28640

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe) (according to Swiss-Prot)
  • Protein family: Phe-tRNA synthetase alpha chain type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol Mol Biol Rev: 2009, 73(1);36-61
[PubMed:19258532] [WorldCat.org] [DOI] (I p)