CopA

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  • Description: copper-transporting ATPase, resistance to copper

Gene name copA
Synonyms yvgX
Essential no
Product copper transporting ATPase
Function copper export
MW, pI 85 kDa, 5.484
Gene length, protein length 2409 bp, 803 aa
Immediate neighbours cadA, copZ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvgX context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU33500

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + H2O + Cu1+(In) = ADP + phosphate + Cu1+(Out) (according to Swiss-Prot)
  • Protein family: Type IB subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure: 2RML ( N-terminal soluble domain)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by copper PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References

Chloe Singleton, Nick E Le Brun
The N-terminal soluble domains of Bacillus subtilis CopA exhibit a high affinity and capacity for Cu(I) ions.
Dalton Trans: 2009, (4);688-96
[PubMed:19378562] [WorldCat.org] [DOI] (P p)

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed