LiaH

• Description: protection against daptamycin
  
  

Gene name	liaH
Synonyms	yvqH
Essential	no
Product	unknown
Function	protection against daptamycin
MW, pI	25 kDa, 6.172
Gene length, protein length	675 bp, 225 aa
Immediate neighbours	liaG, liaI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU33120

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: pspA/IM30 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• Swiss prot entry: O32201

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: liaI-liaH-liaG-liaF-liaS-liaR

• [[Sigma factor]]: SigA

• Regulation: induced by bacitracin (LiaR)
  • repressed during logrithmic growth (AbrB) PubMed

• Regulatory mechanism: LiaR: transcription activation
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Thorsten Mascher, Karlsruhe Institute of Technology, Germany link

References

Sina Jordan, Anja Junker, John D Helmann, Thorsten Mascher
Regulation of LiaRS-dependent gene expression in bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system.
J Bacteriol: 2006, 188(14);5153-66
[PubMed:16816187] [WorldCat.org] [DOI] (P p)

1. Jordan, S., A. Junker, J. D. Helmann, and T. Mascher. 2006. Regulation of LiaRS-dependent gene expression in Bacillus subtilis: identification of inhibitor proteins, regulator binding sites, and target genes of a conserved cell envelope stress-sensing two-component system. J. Bacteriol. 188: 5153-5166. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed