Stusti 2018
Contents
- 1 Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
- 1.1 What makes RNA such a special molecule – specific chemical and structural features of RNA
- 1.2 RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
- 1.3 Ribozymes (catalytically active RNAs)(Intro)
- 1.4 The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
- 1.5 The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
- 1.6 Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme & Co
- 1.7 RNA-based second messengers
- 1.8 Riboregulation and virulence, targeting by antibiotics
- 1.9 Riboswitches
- 1.10 Protein- or tRNA-controlled RNA switches
- 1.11 RNA thermometers
- 1.12 The RNA world and evolution
- 1.13 RNA modification
- 1.14 RNA degradation/processing
- 1.15 Regulation by non-coding RNA
- 1.16 RNA dependent DNA Polymerases - from telomerase to retroviruses
- 1.17 RNA dependent RNA Polymerases – the RNA replicase
- 1.18 CRISPR/Cas: Science – the bacterial “immune” system
- 1.19 CRISPR/Cas: Application and groundbreaking perspectives
- 1.20 The mysterious function and role of 6S-RNA and pRNA in bacteria
- 1.21 Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
- 1.22 Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
- 1.23 Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
Die Sprache der RNA: Von RNA-Schaltern zu CRISPR/ Cas
What makes RNA such a special molecule – specific chemical and structural features of RNA
RNA synthesis – DNA and RNA dependent RNA polymerases and primase during transcription, replication and repair
Ribozymes (catalytically active RNAs)(Intro)
The Ribosome - the role and function of ribosomal RNAs and the central dogma of molecular biology
The Splicosome - the mechanism of mRNA splicing – alternative gene expression, genome size definition and phenotype plasticity
Protein independent ribozymes – about Hammerhead, Varkud satellite, hairpin ribozyme & Co
Christian Hammann, Andrej Luptak, Jonathan Perreault, Marcos de la Peña
The ubiquitous hammerhead ribozyme.
RNA: 2012, 18(5);871-85
[PubMed:22454536]
[WorldCat.org]
[DOI]
(I p)
Sidney Altman
Ribonuclease P.
Philos Trans R Soc Lond B Biol Sci: 2011, 366(1580);2936-41
[PubMed:21930585]
[WorldCat.org]
[DOI]
(I p)
David M J Lilley
The Varkud satellite ribozyme.
RNA: 2004, 10(2);151-8
[PubMed:14730013]
[WorldCat.org]
[DOI]
(P p)
R Shippy, R Lockner, M Farnsworth, A Hampel
The hairpin ribozyme. Discovery, mechanism, and development for gene therapy.
Mol Biotechnol: 1999, 12(1);117-29
[PubMed:10554775]
[WorldCat.org]
[DOI]
(P p)
K Kruger, P J Grabowski, A J Zaug, J Sands, D E Gottschling, T R Cech
Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
Cell: 1982, 31(1);147-57
[PubMed:6297745]
[WorldCat.org]
[DOI]
(P p)
RNA-based second messengers
Riboregulation and virulence, targeting by antibiotics
Riboswitches
Protein- or tRNA-controlled RNA switches
RNA thermometers
The RNA world and evolution
RNA modification
RNA degradation/processing
Regulation by non-coding RNA
RNA dependent DNA Polymerases - from telomerase to retroviruses
RNA dependent RNA Polymerases – the RNA replicase
CRISPR/Cas: Science – the bacterial “immune” system
CRISPR/Cas: Application and groundbreaking perspectives
The mysterious function and role of 6S-RNA and pRNA in bacteria
Synthesis, maturation and function of tRNAs – The wobble hypothesis and specific codon usage as a molecular barrier for horizontal gene transfer
Outlook: Finding function in mystery transcripts – eRNAs, long-non coding (lncRNA) and circular RNA (circRNA)
Outlook: RNA and SELEX – new prospects and applications for targeted interference with regulatory pathways
