GdpP
- Description: cyclic di-AMP phosphodiesterase
Gene name | gdpP |
Synonyms | yybT |
Essential | no |
Product | c-di-AMP phosphodiesterase |
Function | control of sporulation initiation, cell wall homeostasis |
Gene expression levels in SubtiExpress: gdpP | |
Metabolic function and regulation of this protein in SubtiPathways: GdpP | |
MW, pI | 74 kDa, 4.865 |
Gene length, protein length | 1977 bp, 659 aa |
Immediate neighbours | rplI, yybS |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
metabolism of signalling nucleotides, membrane proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40510
Phenotypes of a mutant
Database entries
- BsubCyc: BSU40510
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- cyclic dinucleotide phosphodiesterase, hydrolysis of di-cyclic AMP PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- two transmembrane domains at the N-terminus
- a domain that shares minimum sequence homology with Heme-binding Per-ARNT-Sim (PAS) domains (80 aa) PubMed
- degenerate GGDEF domain (aa 173 - 301) PubMed
- DHH/ DHHA1 phosphodiesterase domain PubMed
- Modification:
- Cofactor(s): b-type heme with 1:1 stoichiometry PubMed
- Effectors of protein activity:
Database entries
- BsubCyc: BSU40510
- UniProt: P37484
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
Biological materials
- Mutant:
- GP998 (gdpP::spc), available in Jörg Stülke's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
GdpP homologs in other organisms
Linda M Holland, Sinéad T O'Donnell, Dmitri A Ryjenkov, Larissa Gomelsky, Shawn R Slater, Paul D Fey, Mark Gomelsky, James P O'Gara
A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP.
J Bacteriol: 2008, 190(15);5178-89
[PubMed:18502872]
[WorldCat.org]
[DOI]
(I p)