Zur

• Description: transcriptional repressor, regulates zinc homeostasis
  
  

Gene name	zur
Synonyms	yqfV
Essential	no
Product	transcriptional repressor (Fur family)
Function	regulation of zinc homeostasis (yciC, znuA-znuC-znuB)
Gene expression levels in SubtiExpress: zur
Regulatory function of this protein in SubtiPathways: zur
Metabolic function and regulation of this protein in SubtiPathways: Zur
MW, pI	16 kDa, 4.856
Gene length, protein length	435 bp, 145 aa
Immediate neighbours	yqfW, yqfU
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, phosphoproteins

The gene

Basic information

• Locus tag: BSU25100

Database entries

• BsubCyc: BSU25100

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: Fur family

• Paralogous protein(s): PerR, Fur

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylated on ser/ thr/ tyr PubMed

• Cofactor(s):

• Effectors of protein activity:
  • sequential binding of zinc (two atoms per monomer) results in the activation of Zur and thus in repression of the genes of the Zur regulon PubMed

• Interactions:
  • forms dimers PubMed

• Localization:

Database entries

• BsubCyc: BSU25100

• Structure:

• UniProt: P54479

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: zur PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 130 PubMed
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 419 PubMed

Biological materials

• Mutant:
  • 1A904 ( zur::spec), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage