DhbC

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  • Description: isochorismate synthase

Gene name dhbC
Synonyms
Essential no
Product isochorismate synthase
Function biosynthesis of the siderophore bacillibactin
Gene expression levels in SubtiExpress: dhbC
Metabolic function and regulation of this protein in SubtiPathways:
DhbC
MW, pI 43 kDa, 5.168
Gene length, protein length 1194 bp, 398 aa
Immediate neighbours dhbE, dhbA
Sequences Protein DNA DNA_with_flanks
Genetic context
DhbC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DhbC expression.png















Categories containing this gene/protein

acquisition of iron, iron metabolism, phosphoproteins

This gene is a member of the following regulons

AbrB regulon, Fur regulon

The gene

Basic information

  • Locus tag: BSU31990

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Chorismate = isochorismate (according to Swiss-Prot)
  • Protein family: isochorismate synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Ser-271 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3OS6, (from B. anthracis, 56% identity, 70% similarity)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • the amount of the mRNA is substantially decreased upon depletion of RNase Y PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References