PadC

• Description: phenolic acid decarboxylase
  
  

Gene name	padC
Synonyms	pad, yveH
Essential	no
Product	phenolic acid decarboxylase
Function	resistance to salicylic acid
Gene expression levels in SubtiExpress: padC
MW, pI	18 kDa, 4.871
Gene length, protein length	483 bp, 161 aa
Immediate neighbours	pnbA, yveG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against other toxic compounds (nitric oxide, phenolic acids, flavonoids, oxalate)

This gene is a member of the following regulons

PadR regulon

The gene

Basic information

• Locus tag: BSU34400

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: padC family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2P8G

• UniProt: O07006

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yveF-yveG-padC PubMed

• Expression browser: padC PubMed

• Sigma factor:

• Regulation: induced by phenolic acid (PadR) PubMed

• Regulatory mechanism: PadR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Thi Kim Chi Nguyen, Ngoc Phuong Tran, Jean-François Cavin
Genetic and biochemical analysis of PadR-padC promoter interactions during the phenolic acid stress response in Bacillus subtilis 168.
J Bacteriol: 2011, 193(16);4180-91
[PubMed:21685295] [WorldCat.org] [DOI] (I p)

Ngoc Phuong Tran, Jerôme Gury, Véronique Dartois, Thi Kim Chi Nguyen, Hélène Seraut, Lise Barthelmebs, Patrick Gervais, Jean-François Cavin
Phenolic acid-mediated regulation of the padC gene, encoding the phenolic acid decarboxylase of Bacillus subtilis.
J Bacteriol: 2008, 190(9);3213-24
[PubMed:18326577] [WorldCat.org] [DOI] (I p)

Nguyen Van Duy, Ulrike Mäder, Ngoc Phuong Tran, Jean-François Cavin, Le Thi Tam, Dirk Albrecht, Michael Hecker, Haike Antelmann
The proteome and transcriptome analysis of Bacillus subtilis in response to salicylic acid.
Proteomics: 2007, 7(5);698-710
[PubMed:17295427] [WorldCat.org] [DOI] (P p)

J F Cavin, V Dartois, C Diviès
Gene cloning, transcriptional analysis, purification, and characterization of phenolic acid decarboxylase from Bacillus subtilis.
Appl Environ Microbiol: 1998, 64(4);1466-71
[PubMed:9546183] [WorldCat.org] [DOI] (P p)