YpjD

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  • Description: putative pyrophosphatase

Gene name ypjD
Synonyms jojD
Essential no
Product putative pyrophosphatase
Function unknown
Gene expression levels in SubtiExpress: ypjD
Metabolic function and regulation of this protein in SubtiPathways:
ypjD
MW, pI 12 kDa, 4.952
Gene length, protein length 333 bp, 111 aa
Immediate neighbours dapB, ypjC
Sequences Protein DNA DNA_with_flanks
Genetic context
YpjD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YpjD expression.png















Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

Spx regulon


The gene

Basic information

  • Locus tag: BSU22500

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: 6-phosphogluconate dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced by diamide stess (thiol depletion) (Spx) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Operon and expression

Ahmed Gaballa, Haike Antelmann, Chris J Hamilton, John D Helmann
Regulation of Bacillus subtilis bacillithiol biosynthesis operons by Spx.
Microbiology (Reading): 2013, 159(Pt 10);2025-2035
[PubMed:23894131] [WorldCat.org] [DOI] (I p)

Ahmed Gaballa, Gerald L Newton, Haike Antelmann, Derek Parsonage, Heather Upton, Mamta Rawat, Al Claiborne, Robert C Fahey, John D Helmann
Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.
Proc Natl Acad Sci U S A: 2010, 107(14);6482-6
[PubMed:20308541] [WorldCat.org] [DOI] (I p)