SteT

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  • Description: serine/ threonine exchanger transporter

Gene name steT
Synonyms ykbA
Essential no
Product serine/ threonine exchanger transporter
Function exchange of serine and threonine
Gene expression levels in SubtiExpress: steT
MW, pI 46 kDa, 9.184
Gene length, protein length 1314 bp, 438 aa
Immediate neighbours ykaA, mhqA
Sequences Protein DNA DNA_with_flanks
Genetic context
YkbA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SteT expression.png















Categories containing this gene/protein

transporters/ other, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU12860

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon: steT
  • Regulation: expression activated by glucose (4.2 fold) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Paola Bartoccioni, César Del Rio, Merce Ratera, Lukasz Kowalczyk, Jocelyn M Baldwin, Antonio Zorzano, Matthias Quick, Stephen A Baldwin, José Luis Vázquez-Ibar, Manuel Palacín
Role of transmembrane domain 8 in substrate selectivity and translocation of SteT, a member of the L-amino acid transporter (LAT) family.
J Biol Chem: 2010, 285(37);28764-76
[PubMed:20610400] [WorldCat.org] [DOI] (I p)

Christian A Bippes, Antra Zeltina, Fabio Casagrande, Merce Ratera, Manuel Palacin, Daniel J Muller, Dimitrios Fotiadis
Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter.
J Biol Chem: 2009, 284(28);18651-63
[PubMed:19419962] [WorldCat.org] [DOI] (P p)

Núria Reig, César del Rio, Fabio Casagrande, Mercè Ratera, Josep Lluís Gelpí, David Torrents, Peter J F Henderson, Hao Xie, Stephen A Baldwin, Antonio Zorzano, Dimitrios Fotiadis, Manuel Palacín
Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters.
J Biol Chem: 2007, 282(18);13270-81
[PubMed:17344220] [WorldCat.org] [DOI] (P p)

Hans-Matti Blencke, Georg Homuth, Holger Ludwig, Ulrike Mäder, Michael Hecker, Jörg Stülke
Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways.
Metab Eng: 2003, 5(2);133-49
[PubMed:12850135] [WorldCat.org] [DOI] (P p)