Fbp

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  • Description: fructose-1,6-bisphosphatase, involved in gluconeogenesis

Gene name fbp
Synonyms fdp, yydE
Essential no
Product fructose-1,6-bisphosphatase
Function gluconeogenesis
Gene expression levels in SubtiExpress: fbp
Metabolic function and regulation of this protein in SubtiPathways:
fbp
MW, pI 77 kDa, 5.601
Gene length, protein length 2013 bp, 671 aa
Immediate neighbours yydF, yydD
Sequences Protein DNA DNA_with_flanks
Genetic context
Fbp context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Fbp expression.png




























Categories containing this gene/protein

carbon core metabolism

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU40190

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate (according to Swiss-Prot)
  • Protein family: FBPase class 3 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Y Fujita, K Yoshida, Y Miwa, N Yanai, E Nagakawa, Y Kasahara
Identification and expression of the Bacillus subtilis fructose-1, 6-bisphosphatase gene (fbp).
J Bacteriol: 1998, 180(16);4309-13
[PubMed:9696785] [WorldCat.org] [DOI] (P p)

Y Fujita, E Freese
Isolation and properties of a Bacillus subtilis mutant unable to produce fructose-bisphosphatase.
J Bacteriol: 1981, 145(2);760-7
[PubMed:6257649] [WorldCat.org] [DOI] (P p)

Y Fujita, E Freese
Purification and properties of fructose-1,6-bisphosphatase of Bacillus subtilis.
J Biol Chem: 1979, 254(12);5340-9
[PubMed:221467] [WorldCat.org] (P p)