RsbP

• Description: protein serine phosphatase, energy PP2C, dephosphorylates RsbV
  
  

Gene name	rsbP
Synonyms	yvfP
Essential	no
Product	protein serine phosphatase, energy PP2C
Function	control of SigB activity
Gene expression levels in SubtiExpress: rsbP
Interactions involving this protein in SubtInteract: RsbP
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	45 kDa, 4.827
Gene length, protein length	1209 bp, 403 aa
Immediate neighbours	rsbQ, ganB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein modification, sigma factors and their control

The gene

Basic information

• Locus tag: BSU34110

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: dephosphorylation of RsbV in response to red light, this results in SigB activation PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: N-terminal PAS domain, central coiled-coil domain, C-terminal PP2C phosphatase domain

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • activity is stimulated upon interaction of the RsbP oligomer with RsbQ PubMed

• Interactions:
  • RsbP-RsbV PubMed
  • RsbQ-RsbP PubMed

• Localization:

Database entries

• Structure:

• UniProt: O07014

• KEGG entry: [2]

• E.C. number: 3.1.3.3

Expression and regulation

• Operon:

• Expression browser: rsbP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Chet Price, Davis, USA homepage

References

Reviews

Jon Marles-Wright, Richard J Lewis
The stressosome: molecular architecture of a signalling hub.
Biochem Soc Trans: 2010, 38(4);928-33
[PubMed:20658979] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed

Locke JC, Young JW, Fontes M, Hernández Jiménez MJ, Elowitz MB  
Stochastic pulse regulation in bacterial stress response. 
Science. 2011 334:366-369. 
PubMed:21979936