DapB

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  • Description: dihydrodipicolinate reductase (NADPH)

Gene name dapB
Synonyms
Essential yes PubMed
Product dihydrodipicolinate reductase (NADPH)
Function biosynthesis of lysine and peptidoglycan
Gene expression levels in SubtiExpress: dapB
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr
MW, pI 29 kDa, 5.057
Gene length, protein length 801 bp, 267 aa
Immediate neighbours mgsA, ypjD
Sequences Protein DNA DNA_with_flanks
Genetic context
DapB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
DapB expression.png















Categories containing this gene/protein

cell wall synthesis, biosynthesis/ acquisition of amino acids, Biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

Spx regulon


The gene

Basic information

  • Locus tag: BSU22490

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH (according to Swiss-Prot)
  • Protein family: glucose-6-phosphate dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure: 1YL6 (from Mycobacterium tuberculosis, 46% identity, 67% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
    • induced by diamide stess (thiol depletion) (Spx) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Operon and expression