RapD

• Description: response regulator aspartate phosphatase, controls ComA activity
  
  

Gene name	rapD
Synonyms	ywpA
Essential	no
Product	response regulator aspartate phosphatase
Function	control of ComA-dependent gene expression
Gene expression levels in SubtiExpress: rapD
Interactions involving this protein in SubtInteract: RapD
MW, pI	41 kDa, 7.691
Gene length, protein length	1062 bp, 354 aa
Immediate neighbours	ywpB, flhP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

genetic competence, protein modification, transcription factors and their control, quorum sensing, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

RghR regulon, SigM regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU36380

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: control of ComA-dependent gene expression PubMed

• Protein family: RAP family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94583

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rapD PubMed

• Expression browser: rapD PubMed

• Sigma factor: SigA PubMed, SigM PubMed, SigX PubMed

• Regulation:
  • repressed by RghR PubMed

• Regulatory mechanism:
  • RghR: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Warawan Eiamphungporn, John D Helmann
The Bacillus subtilis sigma(M) regulon and its contribution to cell envelope stress responses.
Mol Microbiol: 2008, 67(4);830-48
[PubMed:18179421] [WorldCat.org] [DOI] (P p)

Mitsuo Ogura, Yasutaro Fujita
Bacillus subtilis rapD, a direct target of transcription repression by RghR, negatively regulates srfA expression.
FEMS Microbiol Lett: 2007, 268(1);73-80
[PubMed:17227471] [WorldCat.org] [DOI] (P p)

X Huang, J D Helmann
Identification of target promoters for the Bacillus subtilis sigma X factor using a consensus-directed search.
J Mol Biol: 1998, 279(1);165-73
[PubMed:9636707] [WorldCat.org] [DOI] (P p)