AdhA

• Description: thiol-dependent aldehyde dehydrogenase, repair of damaged thiol-containing proteins
  
  

Gene name	adhA
Synonyms
Essential	no
Product	thiol-dependent aldehyde dehydrogenase, reduction of aldehydes
Function	response to toxic formaldehyde
Gene expression levels in SubtiExpress: adhA
MW, pI	37 kDa, 5.367
Gene length, protein length	1047 bp, 349 aa
Immediate neighbours	yrzP, yraA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against oxidative and electrophile stress

This gene is a member of the following regulons

AdhR regulon

The gene

Basic information

• Locus tag: BSU27010

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: C0SPA5

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: adhA-yraA PubMed

• Expression browser: adhA PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of the toxic carbonyls methylglyoxal and formaldehyde (AdhR) PubMed

• Regulatory mechanism:
  • AdhR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Thi Thu Huyen Nguyen, Warawan Eiamphungporn, Ulrike Mäder, Manuel Liebeke, Michael Lalk, Michael Hecker, John D Helmann, Haike Antelmann
Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR).
Mol Microbiol: 2009, 71(4);876-94
[PubMed:19170879] [WorldCat.org] [DOI] (I p)