SqhC

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  • Description: squalene-hopene cyclase, biosynthesis of sporulenes, protection of the spore against oxidative stress PubMed

Gene name sqhC
Synonyms
Essential no
Product squalene-hopene cyclase
Function biosynthesis of sporulenes
Gene expression levels in SubtiExpress: sqhC
MW, pI 71 kDa, 7.633
Gene length, protein length 1896 bp, 632 aa
Immediate neighbours dhaS, sodF
Sequences Protein DNA DNA_with_flanks
Genetic context
SqhC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SqhC expression.png
























Categories containing this gene/protein

sporulation proteins, resistance against oxidative and electrophile stress

This gene is a member of the following regulons

SigE regulon

The gene

Basic information

  • Locus tag: BSU19320

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Squalene = hop-22(29)-ene (according to Swiss-Prot) production of sporulenes, polycyclic terpenoid lipids PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: expressed during sporulation in the mother cell PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

T Bosak, R M Losick, A Pearson
A polycyclic terpenoid that alleviates oxidative stress.
Proc Natl Acad Sci U S A: 2008, 105(18);6725-9
[PubMed:18436644] [WorldCat.org] [DOI] (I p)