CcdA

• Description: membrane-embedded thiol-disulfide oxidoreductase
  
  

Gene name	ccdA
Synonyms
Essential	no
Product	thiol-disulfide oxidoreductase
Function	cytochrome c synthesis
Gene expression levels in SubtiExpress: ccdA
MW, pI	25 kDa, 9.667
Gene length, protein length	705 bp, 235 aa
Immediate neighbours	ynzD, yneI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

respiration, membrane proteins

The gene

Basic information

• Locus tag: BSU17930

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: dsbD family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P45706

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ccdA-yneI-yneJ PubMed

• Expression browser: ccdA PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lýdur S Erlendsson, Lars Hederstedt
Mutations in the thiol-disulfide oxidoreductases BdbC and BdbD can suppress cytochrome c deficiency of CcdA-defective Bacillus subtilis cells.
J Bacteriol: 2002, 184(5);1423-9
[PubMed:11844773] [WorldCat.org] [DOI] (P p)

N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol Microbiol: 2000, 36(3);638-50
[PubMed:10844653] [WorldCat.org] [DOI] (P p)

T Schiött, L Hederstedt
Efficient spore synthesis in Bacillus subtilis depends on the CcdA protein.
J Bacteriol: 2000, 182(10);2845-54
[PubMed:10781554] [WorldCat.org] [DOI] (P p)

T Schiött, M Throne-Holst, L Hederstedt
Bacillus subtilis CcdA-defective mutants are blocked in a late step of cytochrome c biogenesis.
J Bacteriol: 1997, 179(14);4523-9
[PubMed:9226261] [WorldCat.org] [DOI] (P p)

T Schiött, C von Wachenfeldt, L Hederstedt
Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.
J Bacteriol: 1997, 179(6);1962-73
[PubMed:9068642] [WorldCat.org] [DOI] (P p)