MgtE

• Description: magnesium transport via permease (no H+)
  
  

Gene name	mgtE
Synonyms	ykoK
Essential	no
Product	magnesium transport via permease (no H+)
Function	magnesium uptake
Gene expression levels in SubtiExpress: mgtE
MW, pI	50 kDa, 4.609
Gene length, protein length	1353 bp, 451 aa
Immediate neighbours	ykzO, tnrA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), membrane proteins

This gene is a member of the following regulons

M-box

The gene

Basic information

• Locus tag: BSU13300

Database entries

• DBTBS entry: no entry
• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: SLC41A transporter family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure: 2QBZ (the mgtE riboswitch)

• UniProt: O34442

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: mgtE PubMed

• Sigma factor:

• Regulation: induced at low magnesium concentration (M-box) PubMed

• Regulatory mechanism: M-box: Mg(2+)-responsive riboswitch PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Jaya Sahni, Yumei Song, Andrew M Scharenberg
The B. subtilis MgtE magnesium transporter can functionally compensate TRPM7-deficiency in vertebrate B-cells.
PLoS One: 2012, 7(9);e44452
[PubMed:22970223] [WorldCat.org] [DOI] (I p)

Arati Ramesh, Catherine A Wakeman, Wade C Winkler
Insights into metalloregulation by M-box riboswitch RNAs via structural analysis of manganese-bound complexes.
J Mol Biol: 2011, 407(4);556-70
[PubMed:21315082] [WorldCat.org] [DOI] (I p)

Charles E Dann, Catherine A Wakeman, Cecelia L Sieling, Stephanie C Baker, Irnov Irnov, Wade C Winkler
Structure and mechanism of a metal-sensing regulatory RNA.
Cell: 2007, 130(5);878-92
[PubMed:17803910] [WorldCat.org] [DOI] (P p)

Jeffrey E Barrick, Keith A Corbino, Wade C Winkler, Ali Nahvi, Maumita Mandal, Jennifer Collins, Mark Lee, Adam Roth, Narasimhan Sudarsan, Inbal Jona, J Kenneth Wickiser, Ronald R Breaker
New RNA motifs suggest an expanded scope for riboswitches in bacterial genetic control.
Proc Natl Acad Sci U S A: 2004, 101(17);6421-6
[PubMed:15096624] [WorldCat.org] [DOI] (P p)