TrpP

• Description: L-tryptophan transporter (proton symport)
  
  

Gene name	trpP
Synonyms	yhaG
Essential	no
Product	L-tryptophan transporter (proton symport)
Function	tryptophan uptake
Gene expression levels in SubtiExpress: trpP
Metabolic function and regulation of this protein in SubtiPathways: Phe, Tyr, Trp
MW, pI	18 kDa, 11.155
Gene length, protein length	516 bp, 172 aa
Immediate neighbours	yhzF, serC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transporters/ other, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

TRAP regulon

The gene

Basic information

• Locus tag: BSU10010

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: trpP transporter family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: O07515

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: trpP PubMed

• Expression browser: trpP PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced in the absence of tryptophan (MtrB) PubMed

• Regulatory mechanism:
  • MtrB: translation inhibition at an RNA switch, the MtrB binding site overlaps the Shine-DAlgarno sequence and translation initation region, MtrB binds in the presence of tryptophan PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Helen Yakhnin, Hong Zhang, Alexander V Yakhnin, Paul Babitzke
The trp RNA-binding attenuation protein of Bacillus subtilis regulates translation of the tryptophan transport gene trpP (yhaG) by blocking ribosome binding.
J Bacteriol: 2004, 186(2);278-86
[PubMed:14702295] [WorldCat.org] [DOI] (P p)

J P Sarsero, E Merino, C Yanofsky
A Bacillus subtilis gene of previously unknown function, yhaG, is translationally regulated by tryptophan-activated TRAP and appears to be involved in tryptophan transport.
J Bacteriol: 2000, 182(8);2329-31
[PubMed:10735881] [WorldCat.org] [DOI] (P p)