MrnC

• Description: RNase Mini-III
  
  

Gene name	mrnC
Synonyms	yazC
Essential	no
Product	RNase Mini-III
Function	maturation of 23S rRNA
Gene expression levels in SubtiExpress: mrnC
Metabolic function and regulation of this protein in SubtiPathways: tRNA charging
MW, pI	16 kDa, 9.153
Gene length, protein length	429 bp, 143 aa
Immediate neighbours	cysS, yacO
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

Rnases, translation

This gene is a member of the following regulons

T-box

The gene

Basic information

• Locus tag: BSU00950

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: RNase III family (but lacks the dsRNA-binding domain)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: RplC binding to the precursor 23S rRNA stimulates MrnC activity PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31418

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: gltX-cysE-cysS-mrnC-yacO-yacP PubMed

• Expression browser: mrnC PubMed

• Sigma factor: SigA PubMed

• Regulation: repression by cysteine (T-box) PubMed

• Regulatory mechanism: T-box, overlaps a transcription terminator upstream of cysE: transcription antitermination PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Ciaran Condon, IBPC, Paris, France Homepage

David Bechhofer, Mount Sinai School, New York, USA Homepage