YrhE

• Description: unknown, similar to formate dehydrogenase
  
  

Gene name	yrhE
Synonyms
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: yrhE
MW, pI	108 kDa, 5.16
Gene length, protein length	2940 bp, 980 aa
Immediate neighbours	yrhF, yrhD
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteins of unknown function

The gene

Basic information

• Locus tag: BSU27220

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Formate + NAD⁺ = CO₂ + NADH (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): contains an iron-sulfur cluster

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: Q795Y4

• KEGG entry: [2]

• E.C. number: 1.2.1.2

Additional information

The gene is annotated in KEGG as an ortholog of formate dehydrogenase EC 1.2.1.2. In Swiss-Prot the protein is named “formate dehydrogenase chain A”. In MetaCyc the protein is characterized as “similar to formate dehydrogenase”. No literature/experimental evidence supporting the annotation is available. PubMed

Expression and regulation

• Operon: yrhE-yrhD PubMed

• Expression browser: yrhE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947