Cmk

• Description: cytidylate kinase (CMP, dCMP)
  
  

Gene name	cmk
Synonyms	jofC, ypfC
Essential	yes PubMed
Product	cytidylate kinase (CMP, dCMP)
Function	synthesis of CTP and dCTP
Gene expression levels in SubtiExpress: cmk
Metabolic function and regulation of this protein in SubtiPathways: Pyrimidines, Nucleotides (regulation)
MW, pI	24 kDa, 4.999
Gene length, protein length	672 bp, 224 aa
Immediate neighbours	ypfD, ypfB
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, essential genes

The gene

Basic information

• Locus tag: BSU22890

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + (d)CMP = ADP + (d)CDP (according to Swiss-Prot)

• Protein family: Type 1 subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1CKE (from Escherichia coli, 38% identity, 54% similarity) PubMed

• UniProt: P38493

• KEGG entry: [2]

• E.C. number: 2.7.4.14

Expression and regulation

• Operon:

• Expression browser: cmk PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

C P Schultz, L Ylisastigui-Pons, L Serina, H Sakamoto, H H Mantsch, J Neuhard, O Bârzu, A M Gilles
Structural and catalytic properties of CMP kinase from Bacillus subtilis: a comparative analysis with the homologous enzyme from Escherichia coli.
Arch Biochem Biophys: 1997, 340(1);144-53
[PubMed:9126287] [WorldCat.org] [DOI] (P p)