MdtR

• Description: transcription repressor of the multidrug-resistance mdtR-mdtP operon
  
  

Gene name	mdtR
Synonyms	yusO
Essential	no
Product	transcription repressor (MarR family)
Function	regulation of the multidrug-resistance mdtR-mdtP operon
Gene expression levels in SubtiExpress: mdtR
MW, pI	17 kDa, 6.376
Gene length, protein length	465 bp, 155 aa
Immediate neighbours	yusN, mdtP
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

MdtR regulon

The MdtR regulon:

• mdtR-mdtP

The gene

Basic information

• Locus tag:

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1S3J

• UniProt: O32181

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: mdtR-mdtP PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism: repression by MdtR PubMed

• Additional information:

Biological materials

• Mutant: GP1115 (spc), available in Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Ji-Yun Kim, Takashi Inaoka, Kazutaka Hirooka, Hiroshi Matsuoka, Makiko Murata, Reiko Ohki, Yoshikazu Adachi, Yasutaro Fujita, Kozo Ochi
Identification and characterization of a novel multidrug resistance operon, mdtRP (yusOP), of Bacillus subtilis.
J Bacteriol: 2009, 191(10);3273-81
[PubMed:19286808] [WorldCat.org] [DOI] (I p)