ParC

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  • Description: subunit of DNA topoisomerase IV

Gene name parC
Synonyms grlA
Essential yes PubMed
Product subunit of DNA topoisomerase IV
Function chromosome segregation and compaction
Gene expression levels in SubtiExpress: parC
MW, pI 91 kDa, 6.307
Gene length, protein length 2418 bp, 806 aa
Immediate neighbours parE, ynfC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ParC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ParC expression.png


























Categories containing this gene/protein

DNA condensation/ segregation, essential genes

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

  • Locus tag: BSU18100

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: topoisomerase gyrA/parC subunit family (according to Swiss-Prot)
  • Paralogous protein(s): GyrA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1WP5 (C-terminal domain, Geobacillus stearothermophilus)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References