DegA

• Description: transcriptional activator involved in the degradation of glutamine phosphoribosylpyrophosphate amidotransferase
  
  

Gene name	degA
Synonyms
Essential	no
Product	transcriptional activator (LacI family)
Function	unknown
Gene expression levels in SubtiExpress: degA
MW, pI	36 kDa, 5.784
Gene length, protein length	1011 bp, 337 aa
Immediate neighbours	yisR, iolX
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control

The gene

Basic information

• Locus tag: BSU10840

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P37947

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: degA PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

G Hambraeus, C von Wachenfeldt, L Hederstedt
Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs.
Mol Genet Genomics: 2003, 269(5);706-14
[PubMed:12884008] [WorldCat.org] [DOI] (P p)

L B Bussey, R L Switzer
The degA gene product accelerates degradation of Bacillus subtilis phosphoribosylpyrophosphate amidotransferase in Escherichia coli.
J Bacteriol: 1993, 175(19);6348-53
[PubMed:8407808] [WorldCat.org] [DOI] (P p)