GabR

• Description: transcription activator of gabT-gabD, repressor of gabR
  
  

Gene name	gabR
Synonyms	ycnF
Essential	no
Product	transcription regulator
Function	regulation of gamma-amino butyric acid utilization
Gene expression levels in SubtiExpress: gabR
MW, pI	54 kDa, 6.709
Gene length, protein length	1437 bp, 479 aa
Immediate neighbours	yczG, gabT
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of amino acids, transcription factors and their control

This gene is a member of the following regulons

GabR regulon

The GabR regulon:

• gabT-gabD, gabR

The gene

Basic information

• Locus tag: BSU03890

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • transcription activation of the gabT-gabD operon, transcription repression of gabR PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • activation of gabT-gabD expression is triggered by gamma-amino butyrate and pyridoxalphosphate PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P94426

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: gabR (according to DBTBS)

• Expression browser: gabR PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:
  • GabR: negative autoregulation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Boris R Belitsky
Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator.
J Mol Biol: 2004, 340(4);655-64
[PubMed:15223311] [WorldCat.org] [DOI] (P p)

Boris R Belitsky, Abraham L Sonenshein
GabR, a member of a novel protein family, regulates the utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol Microbiol: 2002, 45(2);569-83
[PubMed:12123465] [WorldCat.org] [DOI] (P p)