Pta

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  • Description: phosphotransacetylase

Gene name pta
Synonyms ipa-88d, ywfJ
Essential no
Product phosphotransacetylase
Function overflow metabolism
Gene expression levels in SubtiExpress: pta
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 34 kDa, 4.649
Gene length, protein length 969 bp, 323 aa
Immediate neighbours cysL, ywfI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Pta context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Pta expression.png




























Categories containing this gene/protein

carbon core metabolism, phosphoproteins

This gene is a member of the following regulons

CcpA regulon

The gene

Basic information

  • Locus tag: BSU37660

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Acetyl-CoA + phosphate = CoA + acetyl phosphate (according to Swiss-Prot)
  • Protein family: phosphate acetyltransferase and butyryltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on (Ser-123 OR Thr-128 OR Ser-129) PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1XCO (complex with acetylphosphate), 1TD9
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expression activated by glucose (2.6 fold) (CcpA) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant: GP668 (aphA3), available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References