BcrC

• Description: undecaprenyl pyrophosphate phosphatase, bacitracin resistance
  
  

Gene name	bcrC
Synonyms	ywoA
Essential	no
Product	undecaprenyl pyrophosphate phosphatase
Function	resistance to bacitracin and oxidative stress
Gene expression levels in SubtiExpress: bcrC
MW, pI	21 kDa, 9.455
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	nrgB, ywnJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell envelope stress proteins (controlled by SigM, V, W, X, Y), heat shock proteins, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

SigI regulon, SigM regulon, SigW regulon, SigX regulon

The gene

Basic information

• Locus tag: BSU36530

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bcrC/ybjG/ywoA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P94571

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: bcrC

• Expression browser: bcrC PubMed

• Sigma factor: SigM PubMed, SigI PubMed, SigW PubMed, SigX PubMed

• Regulation:
  • expression activated by glucose (3.3 fold) PubMed
  • induced by heat shock (SigI) PubMed
  • induced by bacitracin
  • induced by oxidative stress
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

1----

Adrian J Jervis, Penny D Thackray, Chris W Houston, Malcolm J Horsburgh, Anne Moir
SigM-responsive genes of Bacillus subtilis and their promoters.
J Bacteriol: 2007, 189(12);4534-8
[PubMed:17434969] [WorldCat.org] [DOI] (P p)

Remi Bernard, Meriem El Ghachi, Dominique Mengin-Lecreulx, Marc Chippaux, François Denizot
BcrC from Bacillus subtilis acts as an undecaprenyl pyrophosphate phosphatase in bacitracin resistance.
J Biol Chem: 2005, 280(32);28852-7
[PubMed:15946938] [WorldCat.org] [DOI] (P p)

Min Cao, Charles M Moore, John D Helmann
Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.
J Bacteriol: 2005, 187(9);2948-56
[PubMed:15838020] [WorldCat.org] [DOI] (P p)

Thorsten Mascher, Neil G Margulis, Tao Wang, Rick W Ye, John D Helmann
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon.
Mol Microbiol: 2003, 50(5);1591-604
[PubMed:14651641] [WorldCat.org] [DOI] (P p)

2-----