YugK

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  • Description: similar to NADH-dependent butanol dehydrogenase

Gene name yugK
Synonyms
Essential no
Product unknown
Function unknown
MW, pI 43 kDa, 4.642
Gene length, protein length 1170 bp, 390 aa
Immediate neighbours pgi, yugJ
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YugK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YugK expression.png
























Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU31360

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: iron-containing alcohol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s): YugJ

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Laura R Jarboe
YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals.
Appl Microbiol Biotechnol: 2011, 89(2);249-57
[PubMed:20924577] [WorldCat.org] [DOI] (I p)

Original publications

Bauke Oudega, Gregory Koningstein, Luísa Rodrigues, Maria de Sales Ramon, Helmut Hilbert, Andreas Düsterhöft, Thomas M Pohl, Thomas Weitzenegger
Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).
Microbiology (Reading): 1997, 143 ( Pt 8);2769-2774
[PubMed:9274030] [WorldCat.org] [DOI] (P p)

The corresponding protein in E. coli

Changhan Lee, Insook Kim, Junghoon Lee, Kang-Lok Lee, Bumchan Min, Chankyu Park
Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.
J Bacteriol: 2010, 192(16);4205-14
[PubMed:20543070] [WorldCat.org] [DOI] (I p)

José Manuel Pérez, Felipe A Arenas, Gonzalo A Pradenas, Juan M Sandoval, Claudio C Vásquez
Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes.
J Biol Chem: 2008, 283(12);7346-53
[PubMed:18211903] [WorldCat.org] [DOI] (P p)