PrsW

• Description: protease, cleaves RsiW in the presence of antimicrobial peptides
  
  

Gene name	prsW
Synonyms	ypdC
Essential	no
Product	protease
Function	control of SigW activity
Interactions involving this protein in SubtInteract: PrsW
MW, pI	24 kDa, 8.085
Gene length, protein length	654 bp, 218 aa
Immediate neighbours	sleB, ypdA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis, sigma factors and their control, membrane proteins

The gene

Basic information

• Locus tag: BSU22940

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: protease prsW family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • PrsW-RsiW PubMed

• Localization: membrane PubMed

Database entries

• Structure:

• UniProt: P50738

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: prsW PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Thomas Wiegert, University of Bayreuth, Germany Homepage

References

Reviews

Additional reviews: PubMed

Original Publications

Janine Heinrich, Kerstin Hein, Thomas Wiegert
Two proteolytic modules are involved in regulated intramembrane proteolysis of Bacillus subtilis RsiW.
Mol Microbiol: 2009, 74(6);1412-26
[PubMed:19889088] [WorldCat.org] [DOI] (I p)

Janine Heinrich, Thomas Wiegert
YpdC determines site-1 degradation in regulated intramembrane proteolysis of the RsiW anti-sigma factor of Bacillus subtilis.
Mol Microbiol: 2006, 62(2);566-79
[PubMed:17020587] [WorldCat.org] [DOI] (P p)

Craig D Ellermeier, Richard Losick
Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis.
Genes Dev: 2006, 20(14);1911-22
[PubMed:16816000] [WorldCat.org] [DOI] (P p)