LmrA

Gene name	lmrA
Synonyms	lin-2, yccB
Essential	no
Product	transcriptional regulator
Function	regulation of lincomycin resistance
Gene expression levels in SubtiExpress: lmrA
MW, pI	20 kDa, 5.033
Gene length, protein length	564 bp, 188 aa
Immediate neighbours	lmrB, ansZ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription factors and their control, resistance against toxins/ antibiotics

This gene is a member of the following regulons

LmrA regulon

The LmrA regulon:

• lmrA-lmrB, qdoR, qdoI-yxaH

The gene

Basic information

• Locus tag: BSU02680

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): QdoR

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: flavonoids such as quercetin serve as inducers, binding results in release from DNA PubMed

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O34619

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: lmrA-lmrB PubMed

• Expression browser: lmrA PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by flavonoids such as quercetin (LmrA)PubMed

• Regulatory mechanism:
  • LmrA: transcription repression PubMed

• Additional information:
  • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J  
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y. 
Mol Microbiol. 2011 81(6): 1459-1473. 
PubMed:21815947