SpoVC

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  • Description: general stress protein, peptidyl-tRNA hydrolase

Gene name spoVC
Synonyms pth
Essential yes PubMed
Product peptidyl-tRNA hydrolase
Function spore coat formation
MW, pI 20 kDa, 5.58
Gene length, protein length 564 bp, 188 aa
Immediate neighbours ctc, fin
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SpoVC context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

translation, general stress proteins (controlled by SigB), essential genes

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU00530

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA (according to Swiss-Prot)
  • Protein family: PTH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jeanne Menez, Richard H Buckingham, Miklos de Zamaroczy, Celine Karmazyn Campelli
Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable.
Mol Microbiol: 2002, 45(1);123-9
[PubMed:12100553] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)