HxlR

• Description: MarR/DUF24 family transcription activator of the hxlA-hxlB operon
  
  

Gene name	hxlR
Synonyms	yckH
Essential	no
Product	MarR/DUF24 family transcription activator
Function	regulation of the ribulose monophosphate pathway
MW, pI	14 kDa, 6.358
Gene length, protein length	360 bp, 120 aa
Immediate neighbours	hxlA, srfAA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

transcription factors and their control, resistance against oxidative and electrophile stress

The HxlR regulon:

• hxlA-hxlB

The gene

Basic information

• Locus tag: BSU03470

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: MarR/DUF24 family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: formaldehyde stimulates transcription activation by HxlR

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P42406

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: hxlR (according to DBTBS)

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:
  • A ncRNA is predicted between hxlR and srfAA PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

H Yasueda, Y Kawahara, S Sugimoto
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
J Bacteriol: 1999, 181(23);7154-60
[PubMed:10572115] [WorldCat.org] [DOI] (P p)