AhrC

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  • Description: AhrC represses the genes for arginine biosynthesis and activates the genes for arginine catabolism.

Gene name ahrC
Synonyms argR
Essential no
Product transcriptional regulator
Function transcriptional regulator of arginine metabolic genes
Metabolic function and regulation of this protein in SubtiPathways:
Ammonium/ glutamate
MW, pI 16,7 kDa, 5.52
Gene length, protein length 447 bp, 149 amino acids
Immediate neighbours recN, yqxC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AhrC context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, utilization of amino acids, transcription factors and their control

This gene is a member of the following regulons

SR1 regulon

The AhrC regulon

The gene

Basic information

  • Locus tag: BSU24250

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Expression

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transcriptional activator/ repressor of genes involved in arginine metabolism
  • Protein family: argR family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): L-arginine is the co-factor required for transcription repression/ activation
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulatory mechanism:
    • inhibtion of translation upon binding of sr1 to the ahrC mRNA PubMed
  • Additional information:

Biological materials

  • Mutant: GP729 (aphA3), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • Antibody:

Labs working on this gene/protein

Simon Phillips, Leeds University, UK Homepage

Michel Debarbouille, Pasteur Institute, Paris, France Homepage

Your additional remarks

References