Zur

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  • Description: transcriptional repressor, regulates zinc homeostasis

Gene name zur
Synonyms yqfV
Essential no
Product transcriptional repressor
Function regulation of zinc homeostasis
(yciC, znuA-znuC-znuB)
Regulatory function of this protein in SubtiPathways:
Stress
MW, pI 16 kDa, 4.856
Gene length, protein length 435 bp, 145 aa
Immediate neighbours yqfW, yqfU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Zur context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

trace metal homeostasis (Cu, Zn, Ni, Mn, Mo), transcription factors and their control, phosphoproteins

This gene is a member of the following regulons

The Zur regulon

The gene

Basic information

  • Locus tag: BSU25100

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Expression

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: Fur family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylated on ser/ thr/ tyr PubMed
  • Cofactor(s):
  • Effectors of protein activity:
    • sequential binding of zinc (two atoms per monomer) results in the activation of Zur and thus in repression of the genes of the Zur regulon PubMed

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

Your additional remarks

References