Crh

• Description: Cofactor of CcpA transcription factor
  
  

Gene name	crh
Synonyms	yvcM
Essential	no
Product	catabolite repression HPr-like protein
Function	catabolite repression
MW, pI	9,2 kDa, 4.70
Gene length, protein length	255 bp, 85 amino acids
Immediate neighbours	yvcL, yvcN
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry:

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: PtsH,HPr family

• Paralogous protein(s): PtsH

Extended information on the protein

• Kinetic information:

• Domains: HPr domain (1–85)

• Modification: phosphorylation at Ser46 by HPrK

• Cofactor(s):

• Effectors of protein activity:

• Interactions: Crh-ThiC, Crh-MgsA, Crh-GapA, Crh-Hag, Crh-CcpA PubMed, HprK-Crh PubMed

• Localization:

Database entries

• Structure: NCBI, dimer NCBI, CcpA-Crh-dna complex NCBI, dimeric phosphor-Crh NCBI
• Swiss prot entry: [2]

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: yvcI-yvcJ-yvcK-yvcL-crh-yvcN

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Labs working on this gene/protein

Boris Görke, University of Göttingen, Germany Homepage

Anne Galinier, University of Marseille, France

References

1. Juy M, Penin F, Favier A (2003) Dimerization of Crh by reversible 3D domain swapping induces structural adjustments to its monomeric homologue Hpr. J Mol Biol. 332(4):767-76. PubMed