GlvR

• Description: transcriptional activator of the malA-glvR-malP operon
  
  

Gene name	glvR
Synonyms	yfiA, malR
Essential	no
Product	transcriptional activator
Function	regulation of maltose utilization
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	29 kDa, 5.446
Gene length, protein length	762 bp, 254 aa
Immediate neighbours	malA, malP
Gene sequence (+200bp)	Protein sequence
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon, GlvR regulon

The GlvR regulon:

• malA-glvR-malP

The gene

Basic information

• Locus tag: BSU08190

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P54717

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: malA-glvR-malP PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induction by maltose (GlvR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • GlvR: transcription activation PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

H Yamamoto, M Serizawa, J Thompson, J Sekiguchi
Regulation of the glv operon in Bacillus subtilis: YfiA (GlvR) is a positive regulator of the operon that is repressed through CcpA and cre.
J Bacteriol: 2001, 183(17);5110-21
[PubMed:11489864] [WorldCat.org] [DOI] (P p)