PbpB

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Gene name pbpB
Synonyms
Essential yes PubMed
Product penicillin-binding protein 2B
Function septation
MW, pI 79 kDa, 9.234
Gene length, protein length 2148 bp, 716 aa
Immediate neighbours ftsL, spoVD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
PbpB context.gif
This image was kindly provided by SubtiList





Categories containing this gene/protein

cell wall synthesis, essential genes, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU15160

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: transpeptidase family (according to Swiss-Prot)
  • Paralogous protein(s): SpoVD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cell membrane PubMed, extracellular (signal peptide) PubMed, localizes to the sporulation septum during sporulation PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • constitutively expressed PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jeff Errington lab
  • Antibody:

Labs working on this gene/protein

Jeff Errington, Newcastle University, UK homepage

Your additional remarks

References

Additional references: PubMed