DhbF

• Description: involved in 2,3-dihydroxybenzoate biosynthesis
  
  

Gene name	dhbF
Synonyms
Essential	no
Product	unknown
Function	biosynthesis of the siderophore bacillibactin
MW, pI	263 kDa, 4.737
Gene length, protein length	7134 bp, 2378 aa
Immediate neighbours	yukJ, dhbB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU31960

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

acquisition of iron, iron metabolism, membrane proteins, phosphoproteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Ser-988 AND Ser-996 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: membrane PubMed

Database entries

• Structure:

• UniProt: P45745

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: dhbA-dhbC-dhbE-dhbB-dhbF PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by iron starvation (Fur) PubMed

• Regulatory mechanism:
  • Fur: transcription repression PubMed
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: