FtsL

• Description: cell-division protein (septum formation), controls together with EzrA dynamics of the FtsZ ring
  
  

Gene name	ftsL
Synonyms	ylxB, yllD
Essential	yes PubMed
Product	cell-division protein
Function	septum formation
MW, pI	12 kDa, 10.083
Gene length, protein length	351 bp, 117 aa
Immediate neighbours	mraW, pbpB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU15150

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

Categories containing this gene/protein

cell division, essential genes, membrane proteins

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ftsL family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: degraded by RasP, stabilized against RasP cleavage by DivIC PubMed

• Interactions:
  • RasP-FtsL, DivIC-FtsL PubMed
  • PbpB-DivIB-(FtsL-DivIC)2 PubMed, as part of the divisome

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: Q07867

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mraZ-mraW-ftsL-pbpB PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: FtsL is degraded by RasP PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Reviews=

Gu Chen, Xu Zhang
New insights into S2P signaling cascades: regulation, variation, and conservation.
Protein Sci: 2010, 19(11);2015-30
[PubMed:20836086] [WorldCat.org] [DOI] (I p)