LipA
- Description: trigger enzyme: lipoic acid synthase and regulator of comE operon expression <br/><br/>
| Gene name | lipA |
| Synonyms | yutB |
| Essential | Yes PubMed |
| Product | trigger enzyme: lipoic acid synthase |
| Function | lipid metabolism, required for the synthesis of branched-chain amino acids |
| MW, pI | 33 kDa, 8.251 |
| Gene length, protein length | 894 bp, 298 aa |
| Immediate neighbours | yutC, lytH |
| Get the DNA and protein sequences <br/> (Barbe et al., 2009) | |
Genetic context <br/> 
<div align="right"> <small>This image was kindly provided by SubtiList</small></div> | |
Contents
<br/><br/>
The gene
Basic information
- Locus tag: BSU32330
Phenotypes of a mutant
reduced transformation efficiency PubMed, strong inhibition of growth on minimal media PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot) Triacylglycerol + H<sub>2</sub>O = diacylglycerol + a carboxylate (according to Swiss-Prot) required for comEA transcription PubMed
- Protein family: Lipoyl synthase family (according to Swiss-Prot) AB hydrolase superfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: extracellular (signal peptide) PubMed
Database entries
- Structure:
- E.C. number: 2.8.1.8 3.1.1.3]
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
<pubmed>18957862 19028902, 19820084 </pubmed>
