RsbT

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• Description: PP2C activator, protein serine kinase, phosphorylates RsbS, part of the stressosome <br/><br/>

Gene name	rsbT
Synonyms	ycxT
Essential	no
Product	PP2C activator, protein serine kinase
Function	control of SigB activity
Metabolic function and regulation of this protein in SubtiPathways: <br/>Stress
MW, pI	14 kDa, 6.587
Gene length, protein length	399 bp, 133 aa
Immediate neighbours	rsbS, rsbU
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> <div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

• Locus tag: BSU04690

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + a protein = ADP + a phosphoprotein (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: RsbS-RsbT PubMed, RsbR-RsbT, RsbT-RsbU

• Localization:

Database entries

• Structure: 3VY9 (complete stressosome)

• UniProt: P42411

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: rsbR-rsbS-rsbT-rsbU-rsbV-rsbW-sigB-rsbX PubMed

• Sigma factor: SigA PubMed

• Regulation: constitutively expressed PubMed

• Regulatory mechanism:

• Additional information:
  • RsbT is synthesized at the same rate as RsbRA and RsbS, however, the RsbT level in growing B. subtilis is only 10% that of RsbRA, suggesting that the protein is unstable PubMed.

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Bill Haldenwang, San Antonio, USA
• Chet Price, Davis, USA homepage
• Rick Lewis, Newcastle, UK homepage

References

Reviews

<pubmed>19704888 16319496 20658979 </pubmed>

Original Articles

<pubmed>8682789,8002610,8682769,9658013,17303566, 9786195,15090521,10781545, 15583165, 8824586, 10329124,16321960,8808936,15312768,11244072,15342582,20019076, 12499568, 12950928, 16321960, 8955331, 18832644</pubmed>