LuxS

• Description: S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for swarming motility and the formation of biofilms
  
  

Gene name	luxS
Synonyms	ytjB
Essential	no
Product	S-ribosylhomocysteine lyase
Function	methionine salvage
Metabolic function and regulation of this protein in SubtiPathways: Cys, Met & Sulfate assimilation
MW, pI	17 kDa, 5.168
Gene length, protein length	471 bp, 157 aa
Immediate neighbours	ytkA, ytjA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU30670

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione (according to Swiss-Prot)

• Protein family: luxS family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity: subject to feedback inhibition PubMed

• Interactions:

• Localization:

Database entries

• Structure: 1JQW (complex with homocysteine), 1J98

• Swiss prot entry: O34667

• KEGG entry: [3]

• E.C. number: 4.4.1.21

Expression and regulation

• Operon: luxS

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information: subject to feedback inhibition PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

M T Hilgers, M L Ludwig
Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site.
Proc Natl Acad Sci U S A: 2001, 98(20);11169-74
[PubMed:11553770] [WorldCat.org] [DOI] (P p)