BcrC

• Description: undecaprenyl pyrophosphate phosphatase, bacitracin resistance
  
  

Gene name	bcrC
Synonyms	ywoA
Essential	no
Product	undecaprenyl pyrophosphate phosphatase
Function	resistance to bacitracin and oxidative stress
MW, pI	21 kDa, 9.455
Gene length, protein length	579 bp, 193 aa
Immediate neighbours	nrgB, ywnJ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU36530

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bcrC/ybjG/ywoA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: P94571

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: bcrC

• Sigma factor: SigM PubMed, SigI PubMed

• Regulation: expression activated by glucose (3.3 fold) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Blencke et al. (2003) Transcriptional profiling of gene expression in response to glucose in Bacillus subtilis: regulation of the central metabolic pathways. Metab Eng. 5: 133-149 PubMed
2. Jervis et al. 2007. SigM-responsive genes of Bacillus subtilis and their promoters. J. Bacteriol. 189: 4534-4538. PubMed
3. Tseng, C. L., and Shaw, G. C. (2008) Genetic evidence for the actin homolog gene mreBH and the bacitracin resistance gene bcrC as targets of the alternative sigma factor SigI of Bacillus subtilis. J. Bacteriol. 190: 1561-1567. PubMed
4. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed