LiaI

• Description: resistance against oxidative stress and cell wall antibiotics, membrane anchor for LiaH
  
  

Gene name	liaI
Synonyms	yvqI
Essential	no
Product	membrane anchor for LiaH
Function	resistance against oxidative stress and cell wall antibiotics
Gene expression levels in SubtiExpress: liaI
MW, pI	13 kDa, 9.303
Gene length, protein length	378 bp, 126 aa
Immediate neighbours	liaH, yvqJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

resistance against oxidative and electrophile stress, resistance against toxins/ antibiotics, membrane proteins

This gene is a member of the following regulons

LiaR regulon

The gene

Basic information

• Locus tag: BSU33130

Database entries

• BsubCyc: BSU33130

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • LiaI-LiaH PubMed

• Localization:
  • cell membrane PubMed
  • forms highly dynamic membrane-associated foci under non-inducing conditions PubMed
  • co-localizes with LiaH in distinct static spots at the cytoplasma membrane under stress conditions PubMed

Database entries

• BsubCyc: BSU33130

• Structure:

• UniProt: O32202

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • liaI-liaH-liaG-liaF-liaS-liaR PubMed
  • liaI-liaH PubMed

• Expression browser: liaI PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by bacitracin and rhamnolipids (LiaR) PubMed
  • repressed during logarithmic growth (AbrB) PubMed, indirect regulation by AbrB PubMed
  • repressed by glucose (4.3-fold) PubMed

• Regulatory mechanism:
  • LiaR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A980 ( liaI::erm), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: