ResC

• Description: part of heam translocase, required for cytochrome c synthesis
  
  

Gene name	resC
Synonyms	ypxC
Essential	yes PubMed
Product	part of the ResB-ResC haem translocase
Function	cytochrome c biogenesis
Gene expression levels in SubtiExpress: resC
Interactions involving this protein in SubtInteract: ResC
Metabolic function and regulation of this protein in SubtiPathways: ResC
MW, pI	39 kDa, 9.564
Gene length, protein length	1056 bp, 352 aa
Immediate neighbours	resD, resB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

respiration, essential genes, membrane proteins

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, ResD regulon

The gene

Basic information

• Locus tag: BSU23130

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU23130

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed

• Protein family: ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • ResB-ResC PubMed

• Localization: cytoplasma membrane PubMed

Database entries

• BsubCyc: BSU23130

• Structure:

• UniProt: P35162

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: resA-resB-resC-resD-resE PubMed

• Expression browser: resC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed
  • PhoP: transcription activation PubMed
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: